The HPE ProLiant ML350 Gen12 is a next-generation 2-socket tower server engineered for small and medium-sized businesses, branch offices, and edge deployments. Designed to deliver enterprise-class capabilities in a flexible 4U tower (or rack-convertible) chassis, it provides the right balance of performance, scalability, and security for organizations preparing for the future of IT.
Powered by the latest IntelĀ® XeonĀ® 6700 and 6500 series processors, the ML350 Gen12 enables businesses to tackle demanding workloads like virtualization, ERP, and data analytics while maintaining headroom for future expansion. With DDR5 memory, PCIe Gen5 I/O, and modernized cooling options, itās purpose-built for growth.
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Why the ML350 Gen12 Stands Out
- Powerful Compute Options
Supports Intel Xeon 6 P-core processors with up to 86 cores per socket (172 total), delivering exceptional performance for diverse business workloads. - High-Capacity Memory
Up to 8 TB DDR5 RDIMM memory across 32 DIMM slots, with speeds up to 6400 MT/s for high throughput and responsiveness in virtualized or data-intensive environments. - Flexible Expansion
Multiple PCIe Gen5 slots support GPUs, NICs, and storage controllers, making the ML350 adaptable for AI inference, virtualization, or enterprise applications. - Storage Versatility
A modular chassis design accommodates both HDD and NVMe SSD configurations, allowing businesses to tailor storage to their performance and capacity needs. - GPU & Accelerator Ready
The tower form factor offers room for GPUs and accelerators, supporting modern workloads like AI/ML, graphics rendering, and VDI.

Built for Secure, Efficient IT
HPE integrates Silicon Root of Trust for firmware integrity and iLO 7 with Secure Enclave for advanced out-of-band management. With support for post-quantum cryptography, the ML350 Gen12 is engineered for long-term protection against evolving threats.
Energy efficiency is another strength: optimized airflow and optional Direct Liquid Cooling (DLC) reduce operational costs and support sustainability initiatives while maintaining consistent performance.
Available Soon Through Saitech
The HPE ProLiant ML350 Gen12 has been officially announced and will be available through Saitech, an authorized HPE partner, at launch. Businesses seeking a versatile, future-ready server can look forward to early access, customized configurations, and expert deployment support.
For a detailed breakdown of specifications and features, read the full article on eSaitech